Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study.
Identifieur interne : 000055 ( Main/Exploration ); précédent : 000054; suivant : 000056Voriconazole and squamous cell carcinoma after lung transplantation: A multicenter study.
Auteurs : B. Hamandi [Canada] ; C. Fegbeutel [Allemagne] ; F P Silveira [États-Unis] ; E A Verschuuren [Pays-Bas] ; M. Younus [États-Unis] ; J. Mo [États-Unis] ; J. Yan [États-Unis] ; P. Ussetti [Espagne] ; P V Chin-Hong [États-Unis] ; A. Solé [Espagne] ; C L Holmes-Liew [Australie] ; E M Billaud [France] ; P A Grossi [Italie] ; O. Manuel [Suisse] ; D J Levine [États-Unis] ; R G Barbers [États-Unis] ; D. Hadjiliadis [États-Unis] ; J. Aram [États-Unis] ; L G Singer [Canada] ; S. Husain [Canada]Source :
- American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons [ 1600-6143 ] ; 2017.
Abstract
This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplantation during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Nine hundred lung transplant recipients were included. Median follow-up time from transplantation to end of follow-up was 3.51 years. In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Residual confounding could not be ruled out because of the use of proxy variables to control for some confounders. Benefits of voriconazole use when prescribed to lung transplant recipients should be carefully weighed versus the potential risk of SCC. EU PAS registration number: EUPAS5269.
DOI: 10.1111/ajt.14500
PubMed: 28898527
Affiliations:
- Allemagne, Australie, Canada, Espagne, France, Italie, Pays-Bas, Suisse, États-Unis
- Basse-Saxe, Californie, Canton de Vaud, Communauté de Madrid, Groningue (province), Pennsylvanie, Texas, État de New York, Île-de-France
- Groningue, Hanovre, Lausanne, Los Angeles, Madrid, Paris
- Université de Californie du Sud
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Hamandi</name><affiliation wicri:level="1"><nlm:affiliation>Department of Pharmacy, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Department of Pharmacy, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Fegbeutel, C" sort="Fegbeutel, C" uniqKey="Fegbeutel C" first="C" last="Fegbeutel">C. Fegbeutel</name><affiliation wicri:level="3"><nlm:affiliation>Department of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover, Germany.</nlm:affiliation><country xml:lang="fr">Allemagne</country><wicri:regionArea>Department of Cardiothoracic, Transplant, and Vascular Surgery, Hannover Medical School, Hannover</wicri:regionArea><placeName><region type="land" nuts="2">Basse-Saxe</region><settlement type="city">Hanovre</settlement></placeName></affiliation></author><author><name sortKey="Silveira, F P" sort="Silveira, F P" uniqKey="Silveira F" first="F P" last="Silveira">F P Silveira</name><affiliation wicri:level="2"><nlm:affiliation>Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Infectious Diseases, University of Pittsburgh Medical Center, Pittsburgh, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Verschuuren, E A" sort="Verschuuren, E A" uniqKey="Verschuuren E" first="E A" last="Verschuuren">E A Verschuuren</name><affiliation wicri:level="3"><nlm:affiliation>Department of Pulmonary Diseases, University Hospital Groningen, Groningen, the Netherlands.</nlm:affiliation><country xml:lang="fr" wicri:curation="lc">Pays-Bas</country><wicri:regionArea>Department of Pulmonary Diseases, University Hospital Groningen, Groningen</wicri:regionArea><placeName><settlement type="city">Groningue</settlement><region nuts="2" type="province">Groningue (province)</region></placeName></affiliation></author><author><name sortKey="Younus, M" sort="Younus, M" uniqKey="Younus M" first="M" last="Younus">M. Younus</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer Inc., New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer Inc., New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Mo, J" sort="Mo, J" uniqKey="Mo J" first="J" last="Mo">J. Mo</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer Inc., New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer Inc., New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Yan, J" sort="Yan, J" uniqKey="Yan J" first="J" last="Yan">J. Yan</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer Inc., New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer Inc., New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Ussetti, P" sort="Ussetti, P" uniqKey="Ussetti P" first="P" last="Ussetti">P. Ussetti</name><affiliation wicri:level="3"><nlm:affiliation>Respiratory Department, Hospital Puerta de Hierro, Madrid, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Department, Hospital Puerta de Hierro, Madrid</wicri:regionArea><placeName><settlement type="city">Madrid</settlement><region nuts="2" type="region">Communauté de Madrid</region></placeName></affiliation></author><author><name sortKey="Chin Hong, P V" sort="Chin Hong, P V" uniqKey="Chin Hong P" first="P V" last="Chin-Hong">P V Chin-Hong</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of California, San Francisco, San Francisco, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of California, San Francisco, San Francisco, CA</wicri:regionArea><placeName><region type="state">Californie</region></placeName></affiliation></author><author><name sortKey="Sole, A" sort="Sole, A" uniqKey="Sole A" first="A" last="Solé">A. Solé</name><affiliation wicri:level="1"><nlm:affiliation>Respiratory Department, University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia, Spain.</nlm:affiliation><country xml:lang="fr">Espagne</country><wicri:regionArea>Respiratory Department, University and Polytechnic Hospital La Fe, Universidad de Valencia, Valencia</wicri:regionArea><wicri:noRegion>Valencia</wicri:noRegion></affiliation></author><author><name sortKey="Holmes Liew, C L" sort="Holmes Liew, C L" uniqKey="Holmes Liew C" first="C L" last="Holmes-Liew">C L Holmes-Liew</name><affiliation wicri:level="1"><nlm:affiliation>Lung Research, Hanson Institute, and Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide, Australia.</nlm:affiliation><country xml:lang="fr">Australie</country><wicri:regionArea>Lung Research, Hanson Institute, and Department of Thoracic Medicine, Royal Adelaide Hospital, Adelaide</wicri:regionArea><wicri:noRegion>Adelaide</wicri:noRegion></affiliation></author><author><name sortKey="Billaud, E M" sort="Billaud, E M" uniqKey="Billaud E" first="E M" last="Billaud">E M Billaud</name><affiliation wicri:level="3"><nlm:affiliation>Service de Pharmacologie, AP-HP, Hôpital Européen G Pompidou, Paris, France.</nlm:affiliation><country xml:lang="fr">France</country><wicri:regionArea>Service de Pharmacologie, AP-HP, Hôpital Européen G Pompidou, Paris</wicri:regionArea><placeName><region type="region">Île-de-France</region><region type="old region">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Grossi, P A" sort="Grossi, P A" uniqKey="Grossi P" first="P A" last="Grossi">P A Grossi</name><affiliation wicri:level="1"><nlm:affiliation>Infectious Diseases Department, University of Insubria, Varese, Italy.</nlm:affiliation><country xml:lang="fr">Italie</country><wicri:regionArea>Infectious Diseases Department, University of Insubria, Varese</wicri:regionArea><wicri:noRegion>Varese</wicri:noRegion></affiliation></author><author><name sortKey="Manuel, O" sort="Manuel, O" uniqKey="Manuel O" first="O" last="Manuel">O. Manuel</name><affiliation wicri:level="3"><nlm:affiliation>Infectious Diseases Service and Transplantation Center, University Hospital of Lausanne, Lausanne, Switzerland.</nlm:affiliation><country xml:lang="fr">Suisse</country><wicri:regionArea>Infectious Diseases Service and Transplantation Center, University Hospital of Lausanne, Lausanne</wicri:regionArea><placeName><settlement type="city">Lausanne</settlement><region nuts="3" type="region">Canton de Vaud</region></placeName></affiliation></author><author><name sortKey="Levine, D J" sort="Levine, D J" uniqKey="Levine D" first="D J" last="Levine">D J Levine</name><affiliation wicri:level="2"><nlm:affiliation>Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care Medicine, University of Texas Health Science Center San Antonio, San Antonio, TX</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Barbers, R G" sort="Barbers, R G" uniqKey="Barbers R" first="R G" last="Barbers">R G Barbers</name><affiliation wicri:level="4"><nlm:affiliation>Division of Pulmonary and Critical Care, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Division of Pulmonary and Critical Care, Keck School of Medicine, University of Southern California, Los Angeles, CA</wicri:regionArea><placeName><region type="state">Californie</region><settlement type="city">Los Angeles</settlement></placeName><orgName type="university">Université de Californie du Sud</orgName></affiliation></author><author><name sortKey="Hadjiliadis, D" sort="Hadjiliadis, D" uniqKey="Hadjiliadis D" first="D" last="Hadjiliadis">D. Hadjiliadis</name><affiliation wicri:level="2"><nlm:affiliation>Department of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Medicine, University of Pennsylvania, Hospital of the University of Pennsylvania, Philadelphia, PA</wicri:regionArea><placeName><region type="state">Pennsylvanie</region></placeName></affiliation></author><author><name sortKey="Aram, J" sort="Aram, J" uniqKey="Aram J" first="J" last="Aram">J. Aram</name><affiliation wicri:level="2"><nlm:affiliation>Pfizer Inc., New York, NY, USA.</nlm:affiliation><country xml:lang="fr">États-Unis</country><wicri:regionArea>Pfizer Inc., New York, NY</wicri:regionArea><placeName><region type="state">État de New York</region></placeName></affiliation></author><author><name sortKey="Singer, L G" sort="Singer, L G" uniqKey="Singer L" first="L G" last="Singer">L G Singer</name><affiliation wicri:level="1"><nlm:affiliation>Toronto Lung Transplant Program, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Toronto Lung Transplant Program, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author><author><name sortKey="Husain, S" sort="Husain, S" uniqKey="Husain S" first="S" last="Husain">S. Husain</name><affiliation wicri:level="1"><nlm:affiliation>Multi-Organ Transplant Program, University Health Network, Toronto, ON, Canada.</nlm:affiliation><country xml:lang="fr">Canada</country><wicri:regionArea>Multi-Organ Transplant Program, University Health Network, Toronto, ON</wicri:regionArea><wicri:noRegion>ON</wicri:noRegion></affiliation></author></analytic><series><title level="j">American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons</title><idno type="eISSN">1600-6143</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">This study evaluated the independent contribution of voriconazole to the development of squamous cell carcinoma (SCC) in lung transplant recipients, by attempting to account for important confounding factors, particularly immunosuppression. This international, multicenter, retrospective, cohort study included adult patients who underwent lung transplantation during 2005-2008. Cox regression analysis was used to assess the effects of voriconazole and other azoles, analyzed as time-dependent variables, on the risk of developing biopsy-confirmed SCC. Nine hundred lung transplant recipients were included. Median follow-up time from transplantation to end of follow-up was 3.51 years. In a Cox regression model, exposure to voriconazole alone (adjusted hazard ratio 2.39, 95% confidence interval 1.31-4.37) and exposure to voriconazole and other azole(s) (adjusted hazard ratio 3.45, 95% confidence interval 1.07-11.06) were associated with SCC compared with those unexposed after controlling for important confounders including immunosuppressants. Exposure to voriconazole was associated with increased risk of SCC of the skin in lung transplant recipients. Residual confounding could not be ruled out because of the use of proxy variables to control for some confounders. Benefits of voriconazole use when prescribed to lung transplant recipients should be carefully weighed versus the potential risk of SCC. EU PAS registration number: EUPAS5269.</div></front></TEI><affiliations><list><country><li>Allemagne</li><li>Australie</li><li>Canada</li><li>Espagne</li><li>France</li><li>Italie</li><li>Pays-Bas</li><li>Suisse</li><li>États-Unis</li></country><region><li>Basse-Saxe</li><li>Californie</li><li>Canton de Vaud</li><li>Communauté de Madrid</li><li>Groningue (province)</li><li>Pennsylvanie</li><li>Texas</li><li>État de New York</li><li>Île-de-France</li></region><settlement><li>Groningue</li><li>Hanovre</li><li>Lausanne</li><li>Los Angeles</li><li>Madrid</li><li>Paris</li></settlement><orgName><li>Université de Californie du Sud</li></orgName></list><tree><country name="Canada"><noRegion><name sortKey="Hamandi, B" sort="Hamandi, B" uniqKey="Hamandi B" first="B" last="Hamandi">B. Hamandi</name></noRegion><name sortKey="Husain, S" sort="Husain, S" uniqKey="Husain S" first="S" last="Husain">S. Husain</name><name sortKey="Singer, L G" sort="Singer, L G" uniqKey="Singer L" first="L G" last="Singer">L G Singer</name></country><country name="Allemagne"><region name="Basse-Saxe"><name sortKey="Fegbeutel, C" sort="Fegbeutel, C" uniqKey="Fegbeutel C" first="C" last="Fegbeutel">C. Fegbeutel</name></region></country><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Silveira, F P" sort="Silveira, F P" uniqKey="Silveira F" first="F P" last="Silveira">F P Silveira</name></region><name sortKey="Aram, J" sort="Aram, J" uniqKey="Aram J" first="J" last="Aram">J. Aram</name><name sortKey="Barbers, R G" sort="Barbers, R G" uniqKey="Barbers R" first="R G" last="Barbers">R G Barbers</name><name sortKey="Chin Hong, P V" sort="Chin Hong, P V" uniqKey="Chin Hong P" first="P V" last="Chin-Hong">P V Chin-Hong</name><name sortKey="Hadjiliadis, D" sort="Hadjiliadis, D" uniqKey="Hadjiliadis D" first="D" last="Hadjiliadis">D. Hadjiliadis</name><name sortKey="Levine, D J" sort="Levine, D J" uniqKey="Levine D" first="D J" last="Levine">D J Levine</name><name sortKey="Mo, J" sort="Mo, J" uniqKey="Mo J" first="J" last="Mo">J. Mo</name><name sortKey="Yan, J" sort="Yan, J" uniqKey="Yan J" first="J" last="Yan">J. Yan</name><name sortKey="Younus, M" sort="Younus, M" uniqKey="Younus M" first="M" last="Younus">M. Younus</name></country><country name="Pays-Bas"><region name="Groningue (province)"><name sortKey="Verschuuren, E A" sort="Verschuuren, E A" uniqKey="Verschuuren E" first="E A" last="Verschuuren">E A Verschuuren</name></region></country><country name="Espagne"><region name="Communauté de Madrid"><name sortKey="Ussetti, P" sort="Ussetti, P" uniqKey="Ussetti P" first="P" last="Ussetti">P. Ussetti</name></region><name sortKey="Sole, A" sort="Sole, A" uniqKey="Sole A" first="A" last="Solé">A. Solé</name></country><country name="Australie"><noRegion><name sortKey="Holmes Liew, C L" sort="Holmes Liew, C L" uniqKey="Holmes Liew C" first="C L" last="Holmes-Liew">C L Holmes-Liew</name></noRegion></country><country name="France"><region name="Île-de-France"><name sortKey="Billaud, E M" sort="Billaud, E M" uniqKey="Billaud E" first="E M" last="Billaud">E M Billaud</name></region></country><country name="Italie"><noRegion><name sortKey="Grossi, P A" sort="Grossi, P A" uniqKey="Grossi P" first="P A" last="Grossi">P A Grossi</name></noRegion></country><country name="Suisse"><region name="Canton de Vaud"><name sortKey="Manuel, O" sort="Manuel, O" uniqKey="Manuel O" first="O" last="Manuel">O. Manuel</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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